Rashmin C Savani

Rashmin C Savani,

Professor And Chair, Department Of Pediatrics

Department: MD-PEDS-ADMINISTRATION
Business Phone: (352) 273-9001
Business Email: rsavani@ufl.edu

About Rashmin C Savani

Additional Positions:
Nemours Eminent Scholar Chair in Pediatrics
2022 – Current · UF College of Medicine
Physician-in-Chief
2022 – Current · Shands Children's Hospital

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9533-5422

Publications

2022
A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group
Journal of Perinatology. 42(1):58-64 [DOI] 10.1038/s41372-021-01178-4. [PMID] 34354227.
2022
Chronic lung disease in full-term infants: Characteristics and neonatal intensive care outcomes in infants referred to children’s hospitals.
Pediatric pulmonology. 57(9):2082-2091 [DOI] 10.1002/ppul.25983. [PMID] 35578392.
2022
Multicenter study assessing physicians’ and transport teams’ attitudes and expectations about utilizing telemedicine to manage critical neonatal transports.
Journal of telemedicine and telecare. [DOI] 10.1177/1357633X221104563. [PMID] 35765233.
2022
Placental clearance not synthesis tempers exaggerated pro-inflammatory cytokine response in neonates exposed to chorioamnionitis.
Pediatric research. [DOI] 10.1038/s41390-022-02147-z. [PMID] 35690685.
2022
Proteoglycans in Toll-like receptor responses and innate immunity
American Journal of Physiology-Cell Physiology. 323(1):C202-C214 [DOI] 10.1152/ajpcell.00088.2022. [PMID] 35675639.
2021
A brief history of telemedicine and the evolution of teleneonatology.
Seminars in perinatology. 45(5) [DOI] 10.1016/j.semperi.2021.151416. [PMID] 34006382.
2021
Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants.
Pediatric pulmonology. 56(10):3283-3292 [DOI] 10.1002/ppul.25610. [PMID] 34379886.
2021
Cardiovascular impact and sequelae of bronchopulmonary dysplasia
Pediatric Pulmonology. 56(11):3453-3463 [DOI] 10.1002/ppul.25370.
2021
CD44 and RHAMM expression patterns in the human developing lung.
Pediatric research. 89(1):134-142 [DOI] 10.1038/s41390-020-0873-y. [PMID] 32311697.
2021
Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants.
Pediatrics. 148(4) [DOI] 10.1542/peds.2020-014191. [PMID] 34552000.
2021
Development and implementation of a teleneonatology program: Opportunities and challenges.
Seminars in perinatology. 45(5) [DOI] 10.1016/j.semperi.2021.151428. [PMID] 34176650.
2021
Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain.
Pediatric research. 89(4):738-745 [DOI] 10.1038/s41390-020-1017-0. [PMID] 32563183.
2021
Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe?
Pediatric research. 89(4):746-752 [DOI] 10.1038/s41390-020-1021-4. [PMID] 32563184.
2021
Part I. Mechanisms of actions and metabolism of acetaminophen related to the neonatal brain.
Early human development. 159 [DOI] 10.1016/j.earlhumdev.2021.105406. [PMID] 34147307.
2021
Part II. Acetaminophen and closure of ductus arteriosus in the newborns: Mechanisms of action, clinical studies, safety and efficacy.
Early human development. 159 [DOI] 10.1016/j.earlhumdev.2021.105407. [PMID] 34147306.
2021
Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia
Journal of Perinatology. 41(11):2651-2657 [DOI] 10.1038/s41372-021-01165-9. [PMID] 34349231.
2021
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
eLife. 10 [DOI] 10.7554/eLife.68563. [PMID] 34866574.
2021
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2021.03.16.435700. [PMID] 33758854.
2021
TeleNICU: Extending the reach of level IV care and optimizing the triage of patient transfers.
Journal of telemedicine and telecare. [DOI] 10.1177/1357633X211038153. [PMID] 34524916.
2020
Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates.
Neonatology. 117(5):545-554 [DOI] 10.1159/000507584. [PMID] 33075792.
2020
Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant.
The Pediatric infectious disease journal. 39(9):e265-e267 [DOI] 10.1097/INF.0000000000002815. [PMID] 32658097.
2020
The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia.
American journal of respiratory and critical care medicine. 201(10):1174-1176 [DOI] 10.1164/rccm.202002-0277ED. [PMID] 32101467.
2020
Transient neonatal antibiotic exposure increases susceptibility to late-onset sepsis driven by microbiota-dependent suppression of type 3 innate lymphoid cells.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-69797-z. [PMID] 32737397.
2020
Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia
Journal of Perinatology. 40(1):149-156 [DOI] 10.1038/s41372-019-0508-5. [PMID] 31570799.
2019
Ceramides, Autophagy, and Apoptosis Mechanisms of Ventilator-induced Lung Injury and Potential Therapeutic Targets.
American journal of respiratory and critical care medicine. 199(6):687-689 [DOI] 10.1164/rccm.201810-1857ED. [PMID] 30372122.
2019
Early predictors of continuous positive airway pressure failure in preterm neonates.
Journal of perinatology : official journal of the California Perinatal Association. 39(8):1081-1088 [DOI] 10.1038/s41372-019-0392-z. [PMID] 31089256.
2019
Hyaluronan biology: A complex balancing act of structure, function, location and context.
Matrix biology : journal of the International Society for Matrix Biology. 78-79:1-10 [DOI] 10.1016/j.matbio.2019.02.002. [PMID] 30802498.
2019
The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury.
Matrix biology : journal of the International Society for Matrix Biology. 78-79:255-271 [DOI] 10.1016/j.matbio.2018.08.002. [PMID] 30098420.
2018
Fetal-placental crosstalk occurs through fetal cytokine synthesis and placental clearance.
Placenta. 69:1-8 [DOI] 10.1016/j.placenta.2018.07.006. [PMID] 30213477.
2018
Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring.
JCI insight. 3(19) [DOI] 10.1172/jci.insight.99223. [PMID] 30282818.
2018
Modulators of inflammation in Bronchopulmonary Dysplasia.
Seminars in perinatology. 42(7):459-470 [DOI] 10.1053/j.semperi.2018.09.009. [PMID] 30446300.
2018
The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year.
The Journal of pediatrics. 203:218-224.e3 [DOI] 10.1016/j.jpeds.2018.07.035. [PMID] 30172426.
2018
The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content.
Early human development. 127:58-68 [DOI] 10.1016/j.earlhumdev.2018.10.002. [PMID] 30312861.
2017
Impact of the Neonatal Resuscitation Program-Recommended Low Oxygen Strategy on Outcomes of Infants Born Preterm.
The Journal of pediatrics. 191:35-41 [DOI] 10.1016/j.jpeds.2017.08.074. [PMID] 29173319.
2017
Inter-center variation in death or tracheostomy placement in infants with severe bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal Association. 37(6):723-727 [DOI] 10.1038/jp.2016.277. [PMID] 28181997.
2016
Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.
Arteriosclerosis, thrombosis, and vascular biology. 36(2):e9-16 [DOI] 10.1161/ATVBAHA.115.306607. [PMID] 26586662.
2016
Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.
The Journal of biological chemistry. 291(37):19257-8 [DOI] 10.1074/jbc.A116.802400. [PMID] 27613954.
2015
Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension.
Pediatric research. 78(6):634-40 [DOI] 10.1038/pr.2015.166. [PMID] 26322414.
2015
Maternal high-fat diet is associated with impaired fetal lung development.
American journal of physiology. Lung cellular and molecular physiology. 309(4):L360-8 [DOI] 10.1152/ajplung.00105.2015. [PMID] 26092997.
2015
The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.
Nature communications. 6 [DOI] 10.1038/ncomms9977. [PMID] 26611836.
2014
Predicting death or tracheostomy placement in infants with severe bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal Association. 34(7):543-8 [DOI] 10.1038/jp.2014.35. [PMID] 24651732.
2014
Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.
Gut microbes. 5(1):28-39 [DOI] 10.4161/gmic.26489. [PMID] 24637807.
2013
Ephrin-B2 reverse signaling increases α5β1 integrin-mediated fibronectin deposition and reduces distal lung compliance.
American journal of respiratory cell and molecular biology. 49(4):680-7 [DOI] 10.1165/rcmb.2013-0002OC. [PMID] 23742148.
2013
Resuscitation of preterm neonates with limited versus high oxygen strategy.
Pediatrics. 132(6):e1488-96 [DOI] 10.1542/peds.2013-0978. [PMID] 24218465.
2013
Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
Antioxidants & redox signaling. 18(14):1753-64 [DOI] 10.1089/ars.2012.4799. [PMID] 23240585.
2012
A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds.
The American journal of pathology. 181(4):1250-70 [DOI] 10.1016/j.ajpath.2012.06.036. [PMID] 22889846.
2012
Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
PloS one. 7(6) [DOI] 10.1371/journal.pone.0038839. [PMID] 22701723.
2012
Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.
Biomacromolecules. 13(1):12-22 [DOI] 10.1021/bm201143c. [PMID] 22066590.
2012
Neonatal effects of magnesium sulfate given to the mother.
American journal of perinatology. 29(10):795-9 [DOI] 10.1055/s-0032-1316440. [PMID] 22773290.
2012
Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein A-stimulated macrophage chemotaxis.
The Journal of biological chemistry. 287(44):37406-19 [DOI] 10.1074/jbc.M112.360982. [PMID] 22948158.
2012
Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes.
Pediatric research. 71(6):626-32 [DOI] 10.1038/pr.2012.24. [PMID] 22337228.
2011
Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.
Molecular cancer. 10 [DOI] 10.1186/1476-4598-10-30. [PMID] 21429221.
2010
Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.
The Journal of biological chemistry. 285(30):23276-84 [DOI] 10.1074/jbc.M109.093146. [PMID] 20463012.
2009
Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.
The Journal of biological chemistry. 284(17):11309-17 [DOI] 10.1074/jbc.M802400200. [PMID] 19164299.
2009
The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.
Respiratory research. 10(1) [DOI] 10.1186/1465-9921-10-77. [PMID] 19698107.
2008
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
The Journal of experimental medicine. 205(4):915-27 [DOI] 10.1084/jem.20071765. [PMID] 18362172.
2008
S-nitrosylation of surfactant protein-D controls inflammatory function.
PLoS biology. 6(11) [DOI] 10.1371/journal.pbio.0060266. [PMID] 19007302.
2007
ABCA3 is critical for lamellar body biogenesis in vivo.
The Journal of biological chemistry. 282(33):23811-7 [PMID] 17540762.
2007
Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON.
American journal of respiratory cell and molecular biology. 37(2):160-8 [PMID] 17395888.
2007
CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
American journal of respiratory cell and molecular biology. 37(2):248-53 [PMID] 17446529.
2007
Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.
Matrix biology : journal of the International Society for Matrix Biology. 26(1):58-68 [PMID] 17055233.
2007
Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide.
Pediatrics. 119(4):670-8 [PMID] 17403837.
2007
Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation.
American journal of physiology. Lung cellular and molecular physiology. 292(1):L249-57 [PMID] 16997883.
2007
SP-D-deficient mice are resistant to hyperoxia.
American journal of physiology. Lung cellular and molecular physiology. 292(4):L861-71 [PMID] 17158597.
2006
Hormonal regulation of alveolarization: structure-function correlation.
Respiratory research. 7(1) [PMID] 16566837.
2006
Involvement of endothelial CD44 during in vivo angiogenesis.
The American journal of pathology. 169(1):325-36 [PMID] 16816384.
2006
Loss of PECAM-1 function impairs alveolarization.
The Journal of biological chemistry. 281(13):8724-31 [PMID] 16377626.
2006
Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide.
Pediatric research. 59(1):157-62 [PMID] 16326985.
2005
Alveolar surfactant protein D content modulates bleomycin-induced lung injury.
American journal of respiratory and critical care medicine. 172(7):869-77 [PMID] 15994463.
2005
Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury.
American journal of respiratory cell and molecular biology. 33(5):447-54 [PMID] 16037485.
2004
Comfort care of neonates at the end of life.
Neonatal network : NN. 23(5):41-6 [PMID] 15490914.
2003
Heterogeneity of claudin expression by alveolar epithelial cells.
American journal of respiratory cell and molecular biology. 29(1):62-70 [PMID] 12600828.
2003
Midkine: a potential bridge between glucocorticoid and retinoid effects on lung vascular development.
American journal of respiratory cell and molecular biology. 28(1):5-8 [PMID] 12495926.
2003
Morphine enhances HIV infection of neonatal macrophages.
Pediatric research. 54(2):282-8 [PMID] 12736382.
2002
Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation.
American journal of physiology. Lung cellular and molecular physiology. 282(3):L394-404 [PMID] 11839532.
2002
Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2).
The American journal of pathology. 160(4):1495-502 [PMID] 11943733.
2002
Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells.
The American journal of pathology. 161(6):2111-21 [PMID] 12466127.
2001
Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis.
The Journal of biological chemistry. 276(39):36770-8 [PMID] 11448954.
2001
Heterocellular gap junctional communication between alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology. 280(6):L1085-93 [PMID] 11350787.
2001
Hyaluronan serves a novel role in airway mucosal host defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(12):2179-86 [PMID] 11641244.
2001
Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection.
The New England journal of medicine. 345(2):93-7 [PMID] 11450677.
2001
Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C.
American journal of physiology. Lung cellular and molecular physiology. 281(3):L685-96 [PMID] 11504697.
2000
A role for hyaluronan in macrophage accumulation and collagen deposition after bleomycin-induced lung injury.
American journal of respiratory cell and molecular biology. 23(4):475-84 [PMID] 11017912.
2000
Bleomycin-induced pulmonary injury in mice deficient in SPARC.
American journal of physiology. Lung cellular and molecular physiology. 279(4):L743-50 [PMID] 11000135.
2000
Duplication of chromosome region 4q28.3-qter in monozygotic twins with discordant phenotypes.
American journal of medical genetics. 94(2):125-40 [PMID] 10982969.
2000
Ending innovative therapy for infants at the margins of viability: case of twins H.
Journal of perinatology : official journal of the California Perinatal Association. 20(4):251-6 [PMID] 10879340.
2000
Serum hyaluronan and its association with unfavorable histology and aggressiveness of heterotransplanted Wilms’ tumor.
Journal of pediatric surgery. 35(7):1070-8 [PMID] 10917299.
1999
Regulation of gap junction proteins by alveolar epithelial cells in response to injury.
Chest. 116(1 Suppl) [PMID] 10424583.
1998
Hyaluronan receptor expression increases in fetal excisional skin wounds and correlates with fibroplasia.
Journal of pediatric surgery. 33(7):1062-9; discussion 1069 [PMID] 9694095.
1998
Modulation of monocyte-endothelial cell interactions by platelet microparticles.
The Journal of clinical investigation. 102(1):136-44 [PMID] 9649567.
1997
The receptor for hyaluronan-mediated motility is expressed in human renal allografts and is correlated with Banff chronic rejection scores.
Transplantation proceedings. 29(6):2603-4 [PMID] 9290759.
1995
Antenatal indomethacin therapy and bronchopulmonary dysplasia.
The Journal of pediatrics. 127(1):160-1 [PMID] 7608803.
1995
Hyaluronan receptor antagonists alter skin inflammation and fibrosis following injury.
Proceedings of the Western Pharmacology Society. 38:131-6 [PMID] 7480006.
1995
Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM.
The Journal of clinical investigation. 95(3):1158-68 [PMID] 7533785.
1995
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation.
Cell. 82(1):19-26 [PMID] 7541721.
1995
The role of hyaluronan and its receptors in restenosis after balloon angioplasty: development of a potential therapy.
International journal of tissue reactions. 17(4):141-51 [PMID] 8867644.
1994
Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.
The EMBO journal. 13(2):286-96 [PMID] 7508860.
1994
Identification of a novel heparin binding domain in RHAMM and evidence that it modifies HA mediated locomotion of ras-transformed cells.
Journal of cellular biochemistry. 56(4):455-68 [PMID] 7534313.
1994
RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: a mediator in B cell malignancy?
Leukemia & lymphoma. 14(5-6):363-74 [PMID] 7529076.
1993
A rapid, multiwell colorimetric assay for chemotaxis.
Journal of immunological methods. 164(2):149-54 [PMID] 8370922.
1993
Identification of hyaluronan binding proteins using a biotinylated hyaluronan probe.
Connective tissue research. 30(2):117-26 [PMID] 7512013.
1993
Maternal and neonatal hyperparathyroidism as a consequence of maternal renal tubular acidosis.
Pediatrics. 91(3):661-3 [PMID] 8441579.
1990
Air embolism with survival in a neonate.
Pediatric radiology. 20(6):480-2 [PMID] 2202974.
1990
Neonatal radiology casebook. Pericardial effusion as a complication of umbilical catheterization.
Journal of perinatology : official journal of the California Perinatal Association. 10(4):443-5 [PMID] 2277290.

Grants

Jul 2016 ACTIVE
SHANDS Teaching Hospital Award Program (CMN)
Role: Principal Investigator
Funding: UF HEALTH SHANDS CHILDRENS HOSPITAL
Sep 2011 ACTIVE
ADMINISTRATIVE STAFF SUPPORT
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jul 2007 ACTIVE
DOH/CMS Admin Fee Supporting Dept of Pediatrics
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RESEARCH

Contact Details

Phones:
Business:
(352) 273-9001
Emails:
Business:
rsavani@ufl.edu
Addresses:
Business Street:
PO BOX 100296
Gaineville FL 32611