Sergei Zolotukhin

Sergei Zolotukhin, Ph.D.

Professor

Department: MD-PEDS-CELL / MOLEC THERP DIV
Business Phone: (352) 273-8150
Business Email: szlt@ufl.edu

About Sergei Zolotukhin

Dr. Zolotukhin, PhD, is Professor of Pediatrics at University of Florida, a graduate of Kyiv State University (Ukraine). He is leading a research in Directed Evolution of combinatorial AAV capsid libraries, tissue-specific targeting of rAAV, and development of novel platforms for a large-scale rAAV manufacturing.

Publications

2016 Methods in Molecular Biology
2009 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
2005 Expert Opinion on Biological Therapy

Grants

Jul 2020 ACTIVE
Artificial intelligence-directed approach in human tissue manufacturing for therapeutic targeting
SAREPTA THERAPEUTICS · Project Manager
Mar 2020 – Sep 2020
Aavanti Task Order #2 – Molecular biology support for development of rAAV vectors for SARS-CoV2 Vaccine
AAVANTIBIO · Principal Investigator
Sep 2019 ACTIVE
Engineering AAV for safe and efficient gene delivery to the human retina
NATL INST OF HLTH NEI ·
Sep 2019 – Aug 2020
STTR – Phase 2 – Targeting glioblastoma stem-like cells with custom-designed viral vectors
LACERTA THERAPEUTICS · Principal Investigator
Aug 2019 ACTIVE
Development of a Novel AAV Vector Capsid Optimized for OA Gene Therapy
US ARMY MED RES ACQUISITION ·
Apr 2018 – Jun 2019
STTR – Targeting glioblastoma stem-like cells with custom-designed viral vectors
LACERTA THERAPEUTICS · Principal Investigator
Aug 2017 ACTIVE
Optimizing AAV Vectors for Central Nervous System transduction
NATL INST OF HLTH NINDS ·
Jul 2017 – Dec 2019
Use of barcoded genomes to determine the frequency of transduction and gene expression of approximately 34 serotypes/mutants of rAAV in various regions of the primate brain
LACERTA THERAPEUTICS · Principal Investigator
May 2017 ACTIVE
Therapy development for open-angle glaucoma
MICHIGAN STATE UNIV · Project Manager
Feb 2017 – May 2018
Characterization of salivary adiponectin and its effect on taste perception
NATL INST OF HLTH NIDCD ·
Dec 2015 – Nov 2017
AAV-mediated optogenetic gene therapy in bipolar cells
APPLIED GENETICS TECH CORP · Project Manager
May 2015 – Apr 2020
NEXT GENERATION OF RECOMBINANT AAV SEROTYPE VECTORS FOR GENE THERAPY
NATL INST OF HLTH NHLBI · Project Manager
Sep 2014 – Aug 2018
AAV Capsid Library Screening
APPLIED GENETICS TECH CORP · Principal Investigator
Aug 2014 – May 2020
Signaling and targeting of CRTC1-MAML2 fusion oncoprotei
NATL INST OF HLTH · Project Manager
Apr 2014 – May 2019
Developing efficient AAV vectors for photoreceptor targe
NATL INST OF HLTH NEI · Project Manager
Aug 2013 – May 2018
AAV capsids and their cellular interactions
NATL INST OF HLTH NIGMS · Project Manager
Jul 2013 – Jun 2020
Modulation of Taste-Related Behavior by Molecular Mediators of Appetite & Satiety
NATL INST OF HLTH NIDCD · Project Manager

Patents

Issued February 1999
Humanized Green Fluorescent Protein Genes And Methods
#5,874,304
Issued October 1999
Humanized Green Fluorescent Protein Genes and Methods
#5,968,750
Issued February 2000
Humanized Green Fluorescent Protein Genes and Methods
#6,020,192
Issued November 2000
Method of Preparing Recombinant AAV Compositions
#6,146,874
Published January 2003
Adiponectin Gene Therapy
#US-2003-0147855-A1
Published June 2003
Production of Pseudotyped Recombinant AAV Virions
#2007-0015238-A1
Published December 2003
Methods of Preparing Recombinant Adeno-Associated Virus Compositions
#2004/0121444-A1
Issued December 2003
Method of Preparing Recombinant Adeno-Associated Virus Compositions
#6,660,514
Issued August 2004
Methods for Large-Scale Production of Recombinant AAV Vectors
#6,783,972
Published January 2005
A Modified Baculovirus Expression System for Production of Pseudotyped rAAV Vector
#US-2006-0166363-A1
Issued August 2006
Production of Pseudotyped Recombinant AAV Virions
#7,094,604
Issued May 2007
Modified AAV
#7,220,577
Issued May 2013
Tyrosine-Modified Recombinant AAV Vectors for Human Gene Therapy
#8,445,267
Issued March 2014
Stable Insect Cell Lines for Production of rAAV Vectors
#8,679,837
Published May 2014
Capsid-Modified rAAV3 Vector Compositions and Uses in Gene Therapy of Human Liver Cancer (CIP)
#US2016/0333372
Issued August 2014
Therapeutic Methods Based on Tyrosine-Substituted, Capsid-Modified RAAV Vectors (DIV)
#8,802,440
Published September 2014
Synthetic Combinatorial AAV Capsid Library for Targeted Gene Therapy
#2016/0369298
Issued October 2015
Improved Transduction Efficiency, Capsid-Modified RAAV Vectors and Methods of Use (CON)
#9,157,098
Published September 2016
Satiation Peptide Administration
#US2017/0080056
Issued November 2016
Satiation Gut Peptides Gene Therapy for Obesity
#9,492,505
Published April 2017
Expression of PYY and Excendin-4 in Murine Saliva Promotes Weight Loss
#US2017/0326257
Published August 2017
Capsid-Modified rAAV Vectors and Methods of Use (CON)
#US2018/0036428
Issued October 2017
Capsid-Modified rAAV Vectors and Methods of Use (CON)
#9,775,918
Published February 2018
Capsid-Modified rAAV Vector Compositions Having Improved Transduction Efficiencies, and Methods of Use (CON)
#US-2018-0244727
Issued March 2018
Activation of the NF-kB Pathway by AAV Vectors and its Implications in Immune Response and Gene Therapy-CIP
#9,920,097
Issued July 2018
Capsid-Modified rAAV Vector Compositions and Methods Therefor
#10,011,640

Contact Details

Phones:
Business:
(352) 273-8150
Emails:
Business:
szlt@ufl.edu